Aim: To compare gingival tissue response, patient compliance following placement of (Coe Pak™) alone and AgNP membrane (ACTICOAT®) with (Coe Pak™), following Periodontal Flap Surgery.

Methodology: This Split-mouth, comparative study included 11 Chronic periodontitis patients, requiring periodontal flap surgery on contralateral sides of the arch, were selected and divided in 2 arches. Group I: Non-Eugenol periodontal dressing (Coe pack) alone after periodontal flap surgery. Group II: AgNP membrane (ACTICOAT) with Non-Eugenol periodontal dressing (coe-pak) placed after periodontal flap surgery. Clinical parameters included plaque index; bleeding scores recorded on 7th day after flap surgery.

Results: AgNP membrane (ACTICOAT®) with (Coe Pak™) showed comparatively better results than (Coe Pak™) alone when plaque scores, bleeding scores, pain and discomfort scores were compared though the differences were statistically significant, subjects found no unpleasant taste/smell and observed the silver nanoparticles membrane to be better.

Conclusion: AgNP membrane (ACTICOAT®) along with (Coe‑Pak™) showed better patient acceptability, gingival tissue response along with swift healing.