In 2000, platelet-rich fibrin (PRF), the second generation of autologous platelet concentrates gained popularity for various applications in the medical and the dental fields, owing to its potentiality of better wound healing, epithelisation and regenerative property.

In this paper, we report 2 cases of oral lesions which were indicated for biopsy. An excisional biopsy was performed to confirm the provisional diagnosis. However, healing from this type of oral biopsy can take several weeks due to the amount of tissue removed to prevent potentially adverse events following exposure of the bone surface, the biopsy site was managed with the use of PRF membrane. The clinical findings, histologic features and surgical management of the above cases are presented.