Introduction: Temporomandibular disorders (TMDs) are a group of clinical issues that affect either one or both of the masticatory muscles, the temporomandibular joint, and related tissues. It is regarded as a subclass of musculoskeletal illnesses and is the most common source of nondental pain in the orofacial region. The dispute and controversy surrounding the causes of TMDs in dentistry are unlike any other areas due to the lack of scientifically verified proof of a cause-and-effect connection. Occlusion has been acknowledged as a significant etiological or perpetuating component, but the exact extent of its influence has not been determined.

Case Description: A 43 year old female patient complained of pain and clicks in the right temporomandibular joint (TMJ) while opening and closing of mouth, accompanied with pain in neck and episodes of headache. On examination patient had edge to edge bite. On palpation, all muscles of mastication bilaterally were tender including the trapezius and sternocleidomastoid muscle. Patient had occasional clicks in right TMJ. The patient was diagnosed with Myofascial pain and dysfunction syndrome due to occlusal discrepancy with disc de-arrangement of right TMJ. A comprehensive treatment to be conducted in 3 phases was proposed. The objective of treatment was resolution of pain, clicks and aesthetics.

Conclusion: Multidisciplinary approach performed by orofacial pain specialist, orthodontist, prosthodontist and physiotherapist yield in complete resolution of patient’s complaint and improved quality of life, along with good corporation of patient has led to completion of treatment within a time span of 1 year.